目的 探讨西瓜藤乙酸乙酯提取物对糖尿病肾病大鼠肾小管的保护作用。方法 大鼠腹腔注射链脲佐菌素(STZ)建立糖尿病肾病大鼠模型,西瓜藤乙酸乙酯提取物喂养干预治疗。检测血、尿中血糖、血肌酐、尿肌酐、尿清蛋白、血胰岛素等指标,计算内生肌酐清除率(Ccr),并观察大鼠肾脏组织病理学改变。结果 与糖尿病肾病组比较,西瓜藤乙酸乙酯高、中剂量组大鼠血糖、血胰岛素、24 h尿清蛋白排泄量、肾重指数及肾小管损伤指数均明显下降 (P<0.05),内生肌酐清除率升高(P<0.05)。结论 西瓜藤乙酸乙酯提取物具有保护糖尿病肾病大鼠肾小管的作用。
Abstract
OBJECTIVE To investigate the protective renal tubular effects ethyl acetate extract from Citrullus lanatus vine in rats with diabetic nephropathy (DN). METHODS Healthy rates were used to establish DN models by peritoneal injection administration streptozotocin. The levels fasting blood glucose (FBG), fasting blood insulin (FBI), serum creatinine (Scr), urine creatinine (Ucr) and urinary albumin (UAlb) were detected. Pathology live was observed. RESULTS After treatment, ethyl acetate high dose group and medial dose group Citrullus lanatus vine all significantly decreased the levels GLU, FBI, UAlb, KWI and TBI. Meanwhile, Ccr was also improved. CONCLUSION The ethyl acetate extract from Citrullus lanatus vine can protect renal tubular in rats with DN.
关键词
西瓜藤 /
糖尿病肾病 /
肾小管 /
大鼠
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Key words
Citrullus lanatus vine /
diabetic nephropathy /
renal tubular /
rat
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中图分类号：
R965
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参考文献
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脚注
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基金
广西大宗农作物西瓜茎叶活性成分筛选与产品开发;广西科技厅科技攻关项目(桂科攻10124008-12);广西中药药效研究重点实验室开放课题(13-051-06-K4)
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